Direct Modulation of Kir Channel Gating by Membrane Phosphatidylinositol 4,5-Bisphosphate
نویسندگان
چکیده
منابع مشابه
Control of Kir channel gating by cytoplasmic domain interface interactions
Inward rectifier potassium (Kir) channels are expressed in almost all mammalian tissues and play critical roles in the control of excitability. Pancreatic ATP-sensitive K (KATP) channels are key regulators of insulin secretion and comprise Kir6.2 subunits coupled to sulfonylurea receptors. Because these channels are reversibly inhibited by cytoplasmic ATP, they link cellular metabolism with mem...
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The modulation of channel activity by direct interaction with membrane lipids is now an emerging theme in ion channel biology. In particular, phosphoinositides such as phosphatidylinositol 4,5-bisphosphate (PIP 2) are known to regulate the activity of most major classes of ion channel, as well as a number of other membrane transport proteins. The regulation of inwardly rectifying (Kir) potassiu...
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The inwardly rectifying K+ (Kir) current in mammalian retinal pigment epithelial (RPE) cells, which is largely mediated by Kir7.1 channels, is stable in cells dialyzed with MgATP but runs down when intracellular ATP is depleted. A potential mechanism for this rundown is a decrease in phosphatidylinositol 4,5-bisphosphate (PIP2) regeneration by ATP-dependent lipid kinases. Here, we used the whol...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.c500355200